Abstract: Genome and transcriptome engineering have emerged as powerful tools in modern biotechnology, driving advancements in precision medicine and novel therapeutics. In this review, we provide a ...

TransAnnot is a toolkit designed to predict protein functions, identify orthologous relationships, and decipher biological pathways for newly sequenced transcriptomes. Utilizing MMseqs2's fast ...

During development of the human cerebral cortex, multipotent neural progenitors generate excitatory neurons and glial cells. Investigations of the transcriptome and epigenome have revealed important ...

Analyzing a person’s gene expression requires mapping their RNA landscape to a standard reference to gain insight into the degree to which genes are “turned on” and perform functions in the body. But ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.2c07043. Gene information used for primer design (Table 1 ...

Recently developed methods to predict three-dimensional protein structure with high accuracy have opened new avenues for genome and proteome research. We explore a new hypothesis in genome annotation, ...

Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection and answer questions regarding utility in different cancer types, cost-effectiveness and affordability, ...

Despite decades of progress in pancreas biology, the molecular features of pancreatic endocrine progenitors remain elusive, and how different hormone-producing islet endocrine cells choose their fate ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.2c01929. The following data can be found in the Supporting Information ...

Beijing Key Laboratory of Ornamental Plants Germplasm Innovation & Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological ...