The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP ...

SportsLine's model simulated Indianapolis vs. San Francisco on 'MNF' 10,000 times and reveals its NFL picks today ...

Should DFS managers target Brock Purdy or Philip Rivers on tonight's Monday Night Football DraftKings Showdown slate?

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield ...

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

Preview the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.